Delta Air Lines will operate from London Heathrow Airport's Terminal 3 from 14 September.
The move to the terminal, which also hosts Virgin Atlantic, aims to help customers manage their travel plans and any last-minute changes.
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Delta will move its Atlanta, Detroit, Minneapolis, Salt Lake City and Philadelphia flights from Terminal 4 to Terminal 3, where its services to New York-JFK, Boston and Seattle currently operate.
Delta senior vice president for Europe, Middle East and Africa Nat Pieper said: "Our joint venture with Virgin Atlantic is all about making it easy for our customers to connect between our airlines and having our Heathrow service under one roof is crucial to delivering a synched-up, more convenient service.
"This enhances the travel experience for customers flying from Heathrow, one of the world's most important international gateways, and marks a major milestone in our joint venture."
Delta will operate 11 daily flights to eight US cities from Terminal 3.
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By GlobalDataThe summer schedule of the two airlines comprises up to 40 daily flights between North America and the UK, with 28 flights between London Heathrow and the US.
Virgin Atlantic executive vice president for commercial Erik Varwijk said: "We are looking forward to our joint venture partner, Delta, joining us in Terminal 3 at London Heathrow.
"Once the switch goes ahead, our customers can enjoy an even more seamless experience flying from or through London.
"Whether they're flying Virgin Atlantic or Delta, they'll benefit from world-class service from the most punctual trans-Atlantic operators at Heathrow, and one of the world's best airport experiences."
