Australia's Federal Government has approved Adelaide Airport's 2014 Master Plan, which includes a $1bn on-airport investment, leading to 3,500 new jobs over the next five years.
The airport plans to build a hotel, expand the southern end of the main terminal and the international arrivals hall.
Plans also include additional international arrival gates, expanding the main security check point and the construction of additional retail space and airline lounges.
The airport said it will triple its domestic and international terminal aerobridges by 2044 as part of its 30-year vision, housing new-generation aircraft such as the A380 and Dreamliner.
The new airport business district will serve as a worldwide connected hub, with designated industry groups such as mining and resources, freight and logistics, technology, office, warehousing and healthcare.
Adelaide Airport managing director Mark Young said: "Since privatisation in 1998, we've doubled the number of passengers and more than quadrupled the number of international passengers.
"We've also invested more than $500m in infrastructure and facilitated a further $350m in the past ten years alone.
"The approval of our master plan allows us to plan and commit to appropriate levels of infrastructure to stay ahead of this growth and maintain our reputation as one of Australia's most modern airports."
Over the next two decades, Adelaide Airport intends to double the $2bn it already contributes annually to the South Australian economy.